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Science 17 May 1968:
Vol. 160. no. 3829, pp. 789 - 791
DOI: 10.1126/science.160.3829.789
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Articles

Immunoglobulin M: Local Synthesis and Selective Secretion in Patients with Immunoglobulin A Deficiency

P. Brandtzaeg 1, I. Fjellanger 1, and S. T. Gjeruldsen 1

1 Institute of Pathological Anatomy, Rikshospitalet, Oslo, Norway

Local synthesis seems to be decisive for the selective secretion of 19S immunoglobulin M into parotid secretions. The "transport piece" is apparently not involved in the secretion of immunoglobulin M, for there is no association between the two components. The possible significance of the normal association of transport piece with secreted immunoglobulin A remains to be clarified.


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Fine Specificity of Ligand-Binding Domain 1 in the Polymeric Ig Receptor: Importance of the CDR2-Containing Region for IgM Interaction.
M. Roe, I. N. Norderhaug, P. Brandtzaeg, and F.-E. Johansen (1999)
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Induction and Delivery of Mucosal Immune Responses.
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Synthesis and Secretion of Secretory Immunoglobulins: With Special Reference to Dental Diseases.
P. Brandtzaeg (1976)
Journal of Dental Research 55, C102-C114
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Localization of Immunoglobulin A in Electrophoretic Patterns of Proteins from Human Parotid Saliva.
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Journal of Dental Research 51, 1555-1560
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