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Science 3 May 1968:
Vol. 160. no. 3827, pp. 558 - 559
DOI: 10.1126/science.160.3827.558
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Articles

Interferon Production and Action in Mouse, Hamster, and Somatic Hybrid Mouse-Hamster Cells

David H. Carver 1, Dexter S. Y. Seto 2, and Barbara R. Migeon 2

1 Departments of Pediatrics and Microbiology
2 Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

A hybrid mouse-hamster cell line was developed from a mouse cell line which produces a high titer of interferon and is sensitive to its action, and a hamster cell line which produces little interferon and is relatively insensitive to its action. Parental cell lines demonstrated complete species specificity with respect to interferon production and action. The hybrid cells produced interferon (or interferons) effective when tested on the mouse cell line and primary hamster cells; the hybrids were sensitive to the action of both mouse and hamster interferons. Hybrid cells produced ten times more hamster interferon than the parent hamster cell line and were eight times more sensitive to hamster interferon than the parent hamster cell line.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Action of Interferon and Its Inducers Against Nonviral Infectious Agents.
J. Vilcek and R. I. Jahiel (1970)
Arch Intern Med 126, 69-77
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Science. ISSN 0036-8075 (print), 1095-9203 (online)