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Science 3 May 1968:
Vol. 160. no. 3827, pp. 533 - 535
DOI: 10.1126/science.160.3827.533
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Articles

Asparagine Synthetase Activity of Mouse Leukemias

Bernard Horowitz 1, Bertha K. Madras 1, Alton Meister 1, Lloyd J. Old 2, Edward A. Boyse 2, and Elisabeth Stockert 2

1 Department of Biochemistry, Cornell University Medical College, New York
2 Sloan-Kettering Institute for Cancer Research and Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College

Various transplanted leukemias and normal tissues of the mouse were tested for asparagine synthetase activity. Leukemias susceptible to suppression by asparaginase have little or no synthetase activity. In contrast, leukemias insensitive to asparaginase exhibit substantial and often very high asparagine synthetase activity. Asparaginase-resistant variants of sensitive leukemias also have considerable synthetase activity. Thus the requirement by certain malignant cells of exogenous asparagine, which entails sensitivity to asparaginase, may be ascribed to lack of asparagine synthetase. Development of asparaginase-resistant variants from asparaginase-sensitive lines is consistently associated with acquisition of asparagine synthetase activity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Up-regulation of asparagine synthetase expression is not linked to the clinical response L-asparaginase in pediatric acute lymphoblastic leukemia.
I. M. Appel, M. L. den Boer, J. P. P. Meijerink, A. J. P. Veerman, N. C. M. Reniers, and R. Pieters (2006)
Blood 107, 4244-4249
   Abstract »    Full Text »    PDF »
L-Asparaginase-Induced Immunosuppression: Effects on Antibody-Forming Cells and Serum Titers.
A. K. Chakrabarty and H. Friedman (1970)
Science 167, 869-870
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)