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Science 19 April 1968:
Vol. 160. no. 3825, pp. 323 - 325
DOI: 10.1126/science.160.3825.323
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Articles

Tritiated Digoxin Binding to (Na+ + K+)-Activated Adenosine Triphosphatase: Possible Allosteric Site

Arnold Schwartz 1, Hideo Matsui 1, and Arline H. Laughter 1

1 Department of Pharmacology, Baylor University College of Medicine, Texas Medical Center, Houston 77025

Tritiated H3-digoxin specifically binds to a cardiac (Na+ + K+)-activated adenosine triphosphatase. In the presence of adenosine triphosphate and other nucleoside di- and triphosphates, binding is stimulated by sodium ion, the apparent rate constant being similar to that reported for phosphorus-32 incorporation from adenosine triphosphate and for the adenosine triphosphatase activity. In the presence of magnesium, manganese, inorganic phosphate, or other ions, sodium ion inhibits binding. The data support an allosteric type of sodium-potassium ion pump.


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T. A. Kuntzweiler, E. T. Wallick, C. L. Johnson, and J. B Lingrel (1995)
J. Biol. Chem. 270, 16206-16212
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Membrane adenosinetriphosphatase: a digitalis receptor?.
T Akera (1977)
Science 198, 569-574
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Science. ISSN 0036-8075 (print), 1095-9203 (online)