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Science 19 April 1968:
Vol. 160. no. 3825, pp. 319 - 320
DOI: 10.1126/science.160.3825.319
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Articles

Microcirculation: Loss of an Enzyme Activity in Chickens with Hereditary Muscular Dystrophy

C. R. Ashmore 1, L. Doerr 1, and R. G. Somes Jr. 1

1 Department of Poultry Science, University of Connecticut, Storrs

Histochemical localization of an alkalinie phosphatase, with agr-naphthyl phosphate used as substrate, shows that activity in breast muscle from normal chickens is restricted to the microvasculature. In chickens with hereditary muscular dystrophy, this enzyme activity disappears from capillaries and small arterioles before degeneraction of muscle fibers is detectable. This loss is retarded in myopathic chickens that have received oxygen therapy.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Duchenne Muscular Dystrophy: Functional Ischemia Reproduces Its Characteristic Lesions.
J. R. Mendell, W. K. Engel, and E. C. Derrer (1971)
Science 172, 1143-1145
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Histochemical Abnormalities of Skeletal Muscle in Patients with Acute Psychoses.
W. K. Engel and H. Meltzer (1970)
Science 168, 273-275
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Experimental Myopathy After Microarterial Embolization: Comparison With Childhood X-Linked Pseudohypertrophic Muscular Dystrophy.
P. W. Hathaway, W. K. Engel, and H. Zellweger (1970)
Arch Neurol 22, 365-378
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