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Science 19 April 1968:
Vol. 160. no. 3825, pp. 312 - 313
DOI: 10.1126/science.160.3825.312
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Concanavalin A in vivo: Induction of Hemorrhagic Skin Lesions (Arthus-Like Reactions) in Mice

Leon S. Kind 1 and Warren A. Petersen 1

1 Department of Asthma-Allergy, National Jewish Hospital, Denver, Colorado

Concanavalin A injected into the skin of mice induced the formation of hemorrhagic Arthus-like lesions. No lesions resulted if concanavalin A was adsorbed with insoluble a2- macroglobulin or if mice were first treated with nitrogen mustard. The ability of concanavalin A, phytohemagglutinin, or pokeweed mitogen to induce skin lesions seemed to parallel their ability to precipitate serum proteins.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)