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Science 19 April 1968:
Vol. 160. no. 3825, pp. 306 - 309
DOI: 10.1126/science.160.3825.306
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Articles

Cytotoxic Action of Stimulated Lymphocytes on Allogenic and Autologous Erythrocytes

Peter Perlmann 1, Hedvig Perlmann 1, and Göran Holm 1

1 Wenner-Gren Institute for Experimental Biology, University of Stockholm, Stockholm, Sweden

Fowl erythrocytes are lysed when exposed to an excess of fowl blood lymphocytes in the presence of phytohemagglutinin. No significant cell damage is seen in the absence of phytohemagglutinin, or when the lymphocytes are replaced by malignant lymphoid cells, thymus cells, or nonlymphoid cells. The lymphocytes remain viable during the reaction. Differences in histocompatibility between lymphocytes and erythrocytes are not required. Autologous lymphocytes are cytotoxic to the same extent as allogenic lymphocytes over a wide range of experimental conditions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ihibition of Cytotoxicity of Lymphocytes by Concanavalin A in vitro.
P. Perlmann, H. Nilsson, and M. A. Leon (1970)
Science 168, 1112-1115
   Abstract »    PDF »
Cytotoxic Effects of Leukocytes Triggered by Complement Bound to Target Cells.
P. Perlmann, H. Perlmann, H. J. Muller-Eberhard, and J. A. Manni (1969)
Science 163, 937-939
   Abstract »    PDF »


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