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Science 29 March 1968:
Vol. 159. no. 3822, pp. 1483 - 1485
DOI: 10.1126/science.159.3822.1483
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Articles

Human Granulocyte Collagenase

Gerald S. Lazarus 1, Robert S. Brown 2, John R. Daniels 3, and Harold M. Fullmer 3

1 National Institute of Dental Research, National Institutes of Health
2 National Cancer Institute, National Institutes of Health
3 National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014

A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete products characteristic of other animal collagenases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Identification of Collagenase in Cultured Blood Mononuclear Cells.
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Platelet factor 4: an inhibitor of collagenase.
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Collagenolysis by Human Gingival Fibroblast Cell Lines.
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Leukocytoclastic Vasculitis.
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Cornea and Sclera.
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Immune Response to Clostridial Collagenase in Gingiva and other Tissues of the Rabbit.
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Journal of Dental Research 51, 293-301
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Human Gingival Collagenase: Purification, Molecular Weight, and Inhibitor Studies.
H. M. Fullmer, R. E. Taylor, and R. W. Guthrie (1972)
Journal of Dental Research 51, 349-355
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Collagenolysis in Cultured Tissue: I. Digestion of Mesenteric Fibers by Enzymes from Explanted Gingival Tissue.
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Journal of Dental Research 50, 1294-1300
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Collagenase and Periodontal Diseases: A Review.
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Journal of Dental Research 50, 288-291
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Bullous Pemphigoid: Is It an Immunologic Disease?.
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Pathogenesis of Ulcers of the Alkali-Burned Cornea.
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Arch Ophthalmol 83, 205-208
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Cell Origin of Collagenase in Normal and Wounded Corneas.
S. I. Brown and C. A. Weller (1970)
Arch Ophthalmol 83, 74-77
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Relationship Between Epithelium and Connective Tissue in Gingival Inflammation.
B. M. Levy, A. C. Taylor, and S. Bernick (1969)
Journal of Dental Research 48, 625-629
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The Origin of Collagenase in Periodontal Tissues of Man.
H. M. Fullmer, W. A. Gibson, G. S. Lazarus, H. A. Bladen, and K. A. Whedon (1969)
Journal of Dental Research 48, 646-651
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Collagenolytic Activity of Alkali-Burned Corneas.
S. I. Brown, C. A. Weller, and H. E. Wassermann (1969)
Arch Ophthalmol 81, 370-373
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Subcellular Distribution and Cytokine- and Chemokine-regulated Secretion of Leukolysin/MT6-MMP/MMP-25 in Neutrophils.
T. Kang, J. Yi, A. Guo, X. Wang, C. M. Overall, W. Jiang, R. Elde, N. Borregaard, and D. Pei (2001)
J. Biol. Chem. 276, 21960-21968
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Science. ISSN 0036-8075 (print), 1095-9203 (online)