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Science 29 March 1968:
Vol. 159. no. 3822, pp. 1479 - 1480
DOI: 10.1126/science.159.3822.1479
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Articles

Genetic Control of Drug Levels in Man: Phenylbutazone

Elliot S. Vesell 1 and John G. Page 1

1 Section on Pharmacogenetics, Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda, Maryland 20014

Phenylbutazone was administered to seven pairs of identical (monozygotic) twins and to seven pairs of fraternal (dizygotic) twins. Individual half-lives ranged from 1.2 to 7.3 days. Subjects with identical genotypes (monozygotic twins) exhibited very similar phenylbutazone half-lives; significantly greater differences in half-life occurred in dizygotic twins. The previously established large variations among individuals in phenylbutazone metabolism appear to be genetically, rather than environmentally, determined.


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