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Science 29 March 1968:
Vol. 159. no. 3822, pp. 1476 - 1477
DOI: 10.1126/science.159.3822.1476
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Articles

Neoplastic Transformation of Hamster Astrocytes in vitro by Simian Virus 40 and Polyoma Virus

Harvey M. Shein 1

1 McLean Hospital Research Laboratory, Belmont, Massachusetts, and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts

Astrocytes in cultures of brain cells from fetal or newborn hamsters undergo neoplastic transformation after infection with simian virus 40 or polyoma virus. Subcutaneous or intracerebral inoculation of the transformed brain cells into newborn or adult hamsters produces progressively enlarging astrocytomas at the sites of injection. Astrocytomas produced by polyomatransformed cell lines are histologically better differentiated, but grow more rapidly and metastasize more frequently, than astrocytomas produced by cell lines transformed by simian virus 40. These observations make available in vitro models of virus-induced oncogenesis in astrocytes and provide simple techniques for obtaining astrocytoma cell lines suitable for screening studies of chemical agents effective against astrocytomas.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chronic Herpes Simplex Virus Infection: Initiation in Hamsters Upon Implantation of Infected Nonpermissive Glial Cells.
J. Schwartz and T. S. Elizan (1973)
Arch Neurol 28, 224-230
   Abstract »    PDF »
Progressive Multifocal Leukoencephalopathy: Identification of Virions in Paraffin-Embedded Tissues.
R. Morecki and R. S. Porro (1970)
Arch Neurol 22, 253-258
   Abstract »    PDF »


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