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Science 15 March 1968:
Vol. 159. no. 3820, pp. 1250 - 1251
DOI: 10.1126/science.159.3820.1250
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Articles

Pathogenesis of a Local Graft versus Host Reaction: Immunogenicity of Circulating Host Leukocytes

William L. Elkins 1 and Ronald D. Guttmann 2

1 Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia 19104
2 Peter Bent Brigham Hospital and Harvard Medical School, Boston, Massachusetts 02115

A local invasive-destructive reaction typical of that seen in allograft rejection occurs when Lewis rat spleen cells are inoculated under the capsule of Lewis kidney freshly grafted into F1 hybrid hosts. Thus the donor lymphoid cells can be immunogenically stimulated by circulating host leukocytes and the interaction of these two cell populations results in nonspecific damage to kidney parenchyma. The results indicate that passenger leukocytes in organ allografts may be important immunogenic agents.


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Antigen Localization and Migration in Immunity and Tolerance.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)