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Science 15 March 1968:
Vol. 159. no. 3820, pp. 1247 - 1249
DOI: 10.1126/science.159.3820.1247
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Articles

Apparent Production of Two Types of Antibodies by a Single Cell

J. Gabriel Michael 1 and Robert Marcus 1

1 Department of Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219

Immunization of mice with bacterial, sheep red cells coated with antigen resulted in apparent production of antibody-forming plaques with specificities for both hemolysis and bactericidal activity. The secondary response for production of these bifunctional types of plaques could be induced by red blood cells or bacteria alone. A significant mutual suppression of immune response between the two immunizing agents was observed.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)