Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 15 March 1968:
Vol. 159. no. 3820, pp. 1243 - 1244
DOI: 10.1126/science.159.3820.1243
Prev | Table of Contents | Next

Articles

Transformation of Human Lymphocytes: Inhibition by Homologous Alpha Globulin

Sidney R. Cooperband 1, Helge Bondevik 1, Karl Schmid 1, and John A. Mannick 1

1 Departments of Medicine, Microbiology, Biochemistry, and Surgery, Boston University School of Medicine, Boston, Massachusetts 02118

An alpha globulin fraction prepared from normal human plasma by column chromatography prevents homologous lymphocyte transformation and the stimulation of DNA, and also protein synthesis induced by phytohemagglutinin and specific antigens. These observations support the concept of a normal circulating immunosuppressant factor which prevents lymphoid cell proliferation.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)