Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 8 March 1968:
Vol. 159. no. 3819, pp. 1104 - 1105
DOI: 10.1126/science.159.3819.1104
Prev | Table of Contents | Next

Articles

Brain Receptors Sensitive to Indole Compounds: Function in Control of Luteinizing Hormone Secretion

F. Fraschini 1, B. Mess 1, F. Piva 1, and L. Martini 1

1 Department of Pharmacology, University of Milan, Milan, Italy

The placement of melatonin and of 5-hydroxytryptophol in the median eminence of castrated male rats is followed 5 days later by a significant decrease in pituitary stores of luteinizing hormone. Pituitary reserve of this hormone is also depleted after the implantation of melatonin, 5-hydroxytryptophol, and 5-methoxytryptophol in the reticular formation of the midbrain. It is suggested that these indole compounds, which are normally synthesized in the pineal gland, may intervene in the control of the secretion of luteinizing hormone, possibly by acting on specific receptors localized in the median eminence and in the midbrain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Brain Serotonin Concentration: Elevation Following Intraperitoneal Administration of Melatonin.
F. Anton-Tay, C. Chou, S. Anton, and R. J. Wurtman (1968)
Science 162, 277-278
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)