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Science 1 March 1968:
Vol. 159. no. 3818, pp. 997 - 999
DOI: 10.1126/science.159.3818.997
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Articles

Mitochondrial Malate Dehydrogenase: Reversible Denaturation Studies

Alan N. Schechter 1 and Charles J. Epstein 1

1 National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014

The malate dehydrogenase isoenzymes from the mitochondria of chicken hearts have been partially resolved into separate pools. Reversible denaturation, in concentrated guanidine hydrochloride, does not change the isoenzyme distribution in each pool. This result suggests that the electrophoretic differences among the isoenzymes are not solely conformational in origin.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)