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Science 1 March 1968:
Vol. 159. no. 3818, pp. 990 - 991
DOI: 10.1126/science.159.3818.990
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Articles

17beta-Estradiol: Inducer of Uterine Hexokinase

J. R. E. Valadares 1, Radhey L. Singhal 1, and M. R. Parulekar 1

1 Department of Pharmacology, University of Ottawa Faculty of Medicine, Ottawa, Canada

Administration of estradiol to ovariectomized rats induced new synthesis of uterine hexokinase which was prevented by actinomycin D, 5-fluorouracil, cycloheximide, or ethionine. The estradiol-induced increase in uterine hexokinase activity was detectable as early as 4 hours. The increase in enzyme activity was dependent upon the dose of the hormone. The evidence indicates that the increased hexokinase activity induced by 17beta-estradiol may entail an acceleration of the synthesis of certain RNA species.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cyclic Adenosine Monophosphate: Andromimetic Action on Seminal Vesicular Enzymes.
R. L. Singhal, R. Vijayvargiya, and G. M. Ling (1970)
Science 168, 261-263
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