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Science 1 March 1968:
Vol. 159. no. 3818, pp. 987 - 990
DOI: 10.1126/science.159.3818.987
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Articles

Murine Hepatitis Virus: Effect on Liver RNA

T. Tsuji 1, B. I. Hirschowitz 1, and G. Sachs 1

1 Division of Gastroenterology, Department of Medicine, University of Alabama Medical Center, Birmingham

After infection of mice with hepatitis virus MHV3, the RNA in the liver undergoes changes. The fraction extracted with phenol at 0°C does not alter. However, the fraction extracted with hot phenol at elevated pH (60°C, pH 8.3) shows a 16S peak on sucrose-density-gradient centrifugation. This fraction shows actinomycin D-resistant incorporation of C14-orotic acid in infected but not in control livers—possible evidence of the RNA nature of MHV3.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)