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Science 9 February 1968:
Vol. 159. no. 3815, pp. 646 - 648
DOI: 10.1126/science.159.3815.646
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Articles

Immunologic Defenses against Metastases: Impairment by Excision of an Allotransplanted Lymphoma

Richard K. Gershon 1, Richard L. Carter 1, and Kazunari Kondo 1

1 Chester Beatty Research Institute, Institute of Cancer Reseach: Royal Cancer Hospital, London, England

Hamsters grafted with an allotransplantable lymphoma that does not metastasize develop a state of concomitant immunity which renders them refractory to reinoculation with cells of the same tumor. Removal of the tumor 7 days after transplantation rapidly leads to a decrease in immunity, the production of enhancing antibodies, and the appearance of metastatic deposits which are probably derived from preexisting tumor cells in the blood and lymphoid tissuces.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)