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Science 2 February 1968:
Vol. 159. no. 3814, pp. 542 - 543
DOI: 10.1126/science.159.3814.542
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Articles

Interferon: Production by Chick Erythrocytes Activated by Cell Fusion

Mary A. Guggenheim 1, Robert M. Friedman 1, and Alan S. Rabson 1

1 National Institutes of Health, Bethesda, Maryland 20014

In the presence of Sendai virus inactivated with ultraviolet light, nucleated chick erythrocytes can be fused with several types of human cells to form heterokaryons. Although chick erythrocytes alone cannot be stimulated by Sendai virus to produce interferon, fusion with a human cell (AH-1) which itself may produce human interferon results in heterokaryons in which the erythrocyte genome is activated and chick interferon is produced. When nucleated chick erythrocytes are fused with another type of human cell (HeLa clone S-3) which does not produce human interferon when stimulated, no chick interferon is detectable, despite morphologic changes suggestive of activation of the erythrocyte nuclei.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cell-Cell Fusion Induced by Measles Virus Amplifies the Type I Interferon Response.
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Interferon Induced by Plasmodium berghei.
K.-Y. Huang, W. W. Schultz, and F. B. Gordon (1968)
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Interferon Production and Action in Mouse, Hamster, and Somatic Hybrid Mouse-Hamster Cells.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)