Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 26 January 1968:
Vol. 159. no. 3813, pp. 442 - 444
DOI: 10.1126/science.159.3813.442
Prev | Table of Contents | Next

Articles

Cysteamine: Differential X-ray Protective Effect on Chinese Hamster Cells During the Cell Cycle

Warren K. Sinclair 1

1 Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois 60439

Cysteamine present during x-irradiation protects synchronized Chinese hamster cells in culture against lethal damage at all stages of the cell cycle. The effect is greatest for cells irradiated at sensitive stages such as G1 and least for resistant cells; for example, late S (dose-modifying factors 4.2 and 2.7, respectively). The effect of 50 millimolar cysteamine is to render almost invariant the normally variant x-ray age response for lethality. This suggests that there are two components of x-ray damage, only one of which is age dependent, and it is against this component that cysteamine protects the cell. Cystamine, however, has no protective effect upon these cells at any stage of the cell cycle.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Rationale for using multiple antioxidants in protecting humans against low doses of ionizing radiation.
K N Prasad (2005)
Br. J. Radiol. 78, 485-492
   Abstract »    Full Text »    PDF »
D-Alpha-Tocopheryl Succinate (Vitamin E) Enhances Radiation-Induced Chromosomal Damage Levels in Human Cancer Cells, but Reduces it in Normal Cells.
B. Kumar, M. N. Jha, W. C. Cole, J. S. Bedford, and K. N. Prasad (2002)
J. Am. Coll. Nutr. 21, 339-343
   Abstract »    Full Text »    PDF »
Scientific Rationale for Using High-Dose Multiple Micronutrients as an Adjunct to Standard and Experimental Cancer Therapies.
K. N. Prasad, W. C. Cole, B. Kumar, and K. C. Prasad (2001)
J. Am. Coll. Nutr. 20, 450S-463
   Abstract »    Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)