Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 26 January 1968:
Vol. 159. no. 3813, pp. 437 - 439
DOI: 10.1126/science.159.3813.437
Prev | Table of Contents | Next

Articles

Leukemia Virus Suppression of Antibody-Forming Cells: Ultrastructure of Infected Spleens

Gloria Chan 1, Martha W. Rancourt 1, Walter S. Ceglowski 1, and Herman Friedman 1

1 Departments of Microbiology, Temple University School of Medicine, and Albert Einstein Medical Center, Phliladelphia, Pennsulvania

Infection of adult BALB/c mice with Friend disease virus results in a leukemia-like disease characterized by erythropoietic changes and splenomegaly. A marked depression of formation of cellular and serum antibody occurs in infected animals. Electron-microscopic examination of the ultrastructure of spleen sections from infected mice with depressed immunity revealed that virus particles can be detected only in immature blastlike lymphoid cells and not in plasmocytes characteristic of the immune response in spleens of noninfected mice immunized with sheep erythrocytes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Leukemia virus-induced immunosuppression: scanning electron microscopy of infected spleen cells.
P Farber, S Specter, and H Friedman (1975)
Science 190, 469-471
   Abstract »    PDF »
Thymus-Dependent Lymphocytes: Destruction by Lymphocytic Choriomeningitis Virus.
M. Hanaoka, S. Suzuki, and J. Hotchin (1969)
Science 163, 1216-1219
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)