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Science 26 January 1968:
Vol. 159. no. 3813, pp. 431 - 432
DOI: 10.1126/science.159.3813.431
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Articles

Specific Inhibition of Viral Ribonucleic Acid Replication by Gliotoxin

P. A. Miller 1, K. P. Milstrey 1, and P. W. Trown 1

1 Lederle Laboratories, Pearl River, New York 10965

Gliotoxin inhibits intracellular replication of poliovirus in HeLa cells at a stage subsequent to adsorption and penetration of virus. The sensitive step is synthesis of viral RNA: synthesis of viral protein is unaffected except as a consequence of blockade of RNA synthesis. Concentrations of gliotoxin sufficient to block viral RNA synthesis completely do not affect cellular RNA synthesis.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)