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Science 26 January 1968:
Vol. 159. no. 3813, pp. 428 - 430
DOI: 10.1126/science.159.3813.428

Articles

Acyl Carrier Protein: Effects of Acetylation and Tryptic Hydrolysis on Function in Fatty Acid Synthesis

Philip W. Majerus 1

1 Departments of Biological Chemistry and Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110

Acetylation of the four lysine residues and the amino group of the terminal serine residue of Escherichia coli acyl carrier protein has no effect on the ability of this protein to function in fatty acid synthesis. Subsequent trypsin hydrolysis resulting in complete inactivation cleaves a single arginyl peptide bond, releasing the amino terminal hexapeptide from the molecule.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)