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Science 5 January 1968:
Vol. 159. no. 3810, pp. 107 - 110
DOI: 10.1126/science.159.3810.107
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Articles

Selective Phagocytosis: A New Concept in Protein Catabolism

H. Gans 1, V. Subramanian 1, and B. H. Tan 1

1 Department of Surgery, University of Minnesota Hospitals, Minneapolis

The clearance of different metabolic products derived from two plasma proteins, prothrombin and fibrinogen, was studied with the aid of the isolated, perfused rat liver. Active thrombin and fibrin were rapidly cleared by the Kupffer cells. Inactive thrombin and a partially degraded fibrin molecule were also cleared but at much slower rates. This difference in clearance rates suggests the presence of a high degree of selectivity in the clearance of altered plasma proteins.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effect of Extracorporeal Circulation on Reticuloendothelial Function: Impairment and Its Relationship to Blood Trauma.
V. Subramanian, J. T. Lowman, and H. Gans (1968)
Arch Surg 97, 330-335
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Science. ISSN 0036-8075 (print), 1095-9203 (online)