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Science 5 January 1968:
Vol. 159. no. 3810, pp. 101 - 103
DOI: 10.1126/science.159.3810.101
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Articles

Induction and Survival of Hemoglobin-Less and Erythrocyte-Less Tadpoles and Young Bullfrogs

Gustavo Flores 1 and Earl Frieden 1

1 Department of Chemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee

Injection of two 25-microgram-per-gram doses of the hemolytic agent phenylhydrazine reduced the hemoglobin level and the erythrocyte count to less than 1 percent of normal tadpole and young blullfrog blood. These anemic animals survive for weeks with little change in overall metabolism. A slow recovery of hemoglobin levels was observed. The implications of this observation for comparative biochemistry are considered.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differentiation of red blood cells in vitro.
R. Broyles and M. Deutsch (1975)
Science 190, 471-473
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Science. ISSN 0036-8075 (print), 1095-9203 (online)