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Science 29 December 1967:
Vol. 158. no. 3809, pp. 1700 - 1701
DOI: 10.1126/science.158.3809.1700
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Articles

Frog Skeletal Muscle Fibers: Changes in Electrical Properties after Disruption of Transverse Tubular System

Robert S. Eisenberg 1 and Peter W. Gage 1

1 Department of Physiology, Duke University Medical Center, Durham, North Carolina

In muscle fibers which have been exposed for 1 hour to a Ringer solution containing 400 millimolar glycerol and then returned to plain Ringer solution, the transverse tubular system is disrupted. At the same time the membrane capacitance is markedly reduced and hyperpolarizing current pulses no longer produce a slow, progressive increase in potential (creep). The large capacitance of muscle and the phenomenon of "creep" must both depend on an intact transverse tubular system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Amantadine: neuromuscular blockade by suppression of ionic conductance of the acetylcholine receptor.
E. Albuquerque, A. Eldefrawi, M. Eldefrawi, N. Mansour, and M. Tsai (1978)
Science 199, 788-790
   Abstract »    PDF »
Excitation-Contraction Uncoupling: The Effect of Hyperosmolar Glycerol Solution and Dantrolene Sodium on Mammalian Muscle in Vitro.
T. Kurihara and J. E. Brooks (1975)
Arch Neurol 32, 92-97
   Abstract »    PDF »
Sarcomeric Oscillations in Frog Skeletal Muscle Fibers.
L. A. Marco and W. L. Nastuk (1968)
Science 161, 1357-1358
   Abstract »    PDF »
Transverse Tubular System in Glycerol-Treated Skeletal Muscle.
B. Eisenberg and R. S. Eisenberg (1968)
Science 160, 1243-1244
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)