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Science 15 December 1967:
Vol. 158. no. 3807, pp. 1482 - 1484
DOI: 10.1126/science.158.3807.1482
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Articles

Control of Aldosterone Secretion by the Pituitary Gland

William P. Palmore 1 and Patrick J. Mulrow 2

1 Departments of Physiology and Internal Medicine, Yale University, New Haven, Connecticut 06510
2 Department of Internal Medicine, Yale University

In the rat, the pituitary gland is essential for the stimulation of aldosterone secretion by sodium depletion. Hypophysectomy abolishes the response to sodium depletion, whereas whole pituitary gland injections partially restore it. The response cannot be restored by injections of either adrenocorticotropin or growth hormone, nor by adrenocorticotropin plus thyroxin. The pituitary gland must secrete a hormone or possibly several hormones which are necessary for the adrenal gland to respond to sodium depletion.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Idiopathic Aldosteronism: A Possible Disease of the Intermediate Lobe of the Pituitary.
R. Franco-Saenz, P. J. Mulrow, and K. Kim (1984)
JAMA 251, 2555-2558
   Abstract »    PDF »
Beta-lipotropin: a new aldosterone-stimulating factor.
H Matsuoka, P. Mulrow, and C. Li (1980)
Science 209, 307-308
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)