Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 15 December 1967:
Vol. 158. no. 3807, pp. 1479 - 1480
DOI: 10.1126/science.158.3807.1479
Prev | Table of Contents | Next

Articles

Pemoline Levels in Brain: Enhancement by Dimethyl Sulfoxide

John J. Brink 1 and Donald G. Stein 1

1 Department of Biology and Psychology, Clark University, Worcester, Massachusetts 01610

Pemoline-C14 dissolved in dimethyl sulfoxide and injected intraperitoneally into rats was found in larger amounts in the brain than was a similar dose given in 0.3 percent tragacanth suspension. This appeared to be related to a partial breakdown of the blood-brain barrier in vivo by the dimethyl sulfoxide.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Morphologic effect of dimethyl sulfoxide on the blood-brain barrier.
R. Broadwell, M Salcman, and R. Kaplan (1982)
Science 217, 164-166
   Abstract »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)