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Science 15 December 1967:
Vol. 158. no. 3807, pp. 1464 - 1467
DOI: 10.1126/science.158.3807.1464
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Articles

Synovial Cell Synthesis of a Substance Immunologically Like Cartilage Proteinpolysaccharide

Rosamond Janis 1, John Sandson 1, Carol Smith 1, and David Hamerman 1

1 Departments of Pathology and Medicine, Albert Einstein College of Medicine, Bronx, New York 10461

Fluids from joints contain a substance that reacts immunologically like one of two known antigenic components of articular cartilage proteinpolysaccharide. This newly recognized substance occurs in the lining cells of synovial membranes as shown by indirect immunofluorescence. The localization of this substance in tissue culture cells derived from synovial membranes and its identification in the culture medium supports the suggestion that it is synthesized by lining cells. Rheumatoid synovial cells contain less of this substance.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)