Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 15 December 1967:
Vol. 158. no. 3807, pp. 1453 - 1455
DOI: 10.1126/science.158.3807.1453
Prev | Table of Contents | Next

Articles

Myxovirus-Like Structures in a Case of Human Chronic Polymyositis

Shi-ming Chou 1

1 Department of Pathology and Regional Primate Research Center, University of Wisconsin Medical School, Madison

Intranuclear and intracytoplasmic aggregates of filaments with tubular structures and transverse striations occurred in muscle tissues biopsied from a patient with chronic polymyositis. The filamentous tubules bear a close resemblance to the incomplete form of myxovirus in which the envelope is missing. Three biopsies from the same patient, taken during a period of 1frac12 years, all revealed these structures. This finding provides presumptive evidence that a chronic persistent viral infection may be involved in the pathogenesis of chronic polymyositis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Polymyositis: An Ongoing Discussion About a Disease Entity.
I. M. Bronner, W. H. J. P. Linssen, M. F. G. van der Meulen, J. E. Hoogendijk, and M. de Visser (2004)
Arch Neurol 61, 132-135
   Abstract »    Full Text »    PDF »
Inclusion body myositis evolving in systemic lupus erythrematosus? A case report.
G. Massawi, P. Hickling, D. Hilton, and C. Patterson (2003)
Rheumatology 42, 1012-1014
   Full Text »    PDF »
Primary Sjogren's syndrome associated with inclusion body myositis.
P. Kanellopoulos, C. Baltoyiannis, and A. G. Tzioufas (2002)
Rheumatology 41, 440-444
   Abstract »    Full Text »    PDF »
Treatment and investigation of idiopathic inflammatory myopathies.
I. Lundberg and Y.-L. Chung (2000)
Rheumatology 39, 7-17
   Full Text »    PDF »
Management of Dysphagia in Inclusion Body Myositis.
D. H. Darrow, H. T. Hoffman, G. J. Barnes, and C. A. Wiley (1992)
Arch Otolaryngol Head Neck Surg 118, 313-317
   Abstract »    PDF »
Amyloid Filaments in Inclusion Body Myositis: Novel Findings Provide Insight Into Nature of Filaments.
J. R. Mendell, Z. Sahenk, T. Gales, and L. Paul (1991)
Arch Neurol 48, 1229-1234
   Abstract »    PDF »
Familial Inclusion Body Myositis Among Kurdish-Iranian Jews.
R. Massa, B. Weller, G. Karpati, E. Shoubridge, and S. Carpenter (1991)
Arch Neurol 48, 519-522
   Abstract »    PDF »
Childhood Onset Inclusion Body Myositis Mimicking Limb-Girdle Muscular Dystrophy.
J. E. Riggs, S. S. Schochet Jr, L. Gutmann, and S. C. Lerfald (1989)
J Child Neurol 4, 283-285
   Abstract »    PDF »
Spectrum of Inclusion Body Myositis.
S. P. Ringel, C. E. Kenny, H. E. Neville, R. Giorno, and M. R. Carry (1987)
Arch Neurol 44, 1154-1157
   Abstract »    PDF »
Inclusion Body Myositis: A Corticosteroid-Resistant Idiopathic Inflammatory Myopathy.
M. J. Danon, M. G. Reyes, O. H. Perurena, J. C. Masdeu, and J. R. Manaligod (1982)
Arch Neurol 39, 760-764
   Abstract »    PDF »
The Myositis of Influenza.
J. D. Mejlszenkier, A. P. Safran, J. J. Healy, L. Embree, and E. M. Ouellette (1973)
Arch Neurol 29, 441-443
   Abstract »    PDF »
Polymyositis With Intranuclear Inclusions: A Light and Electron Microscopic Study.
S. S. Schochet Jr. and W. F. McCormick (1973)
Arch Neurol 28, 280-283
   Abstract »    PDF »
Subacute Inclusion Body Encephalitis Associated With Myopathy.
K. E. Bove and S. A. Shelburne Jr. (1972)
Arch Neurol 27, 42-44
   Abstract »    PDF »
Viruses and the Connective Tissue Diseases.
M. ZIFF (1971)
Ann Intern Med 75, 951-958
   Abstract »    PDF »
Intraendothelial Inclusions in Kidneys of Patients with Systemic Lupus Erythematosus.
C. C. TISHER, H. B. KELSO, R. R. ROBINSON, J. C. GUNNELLS, and P. M. BURKHOLDER (1971)
Ann Intern Med 75, 537-547
   Abstract »    PDF »
Articular Manifestations of Systemic Lupus Erythematosus.
R. LABOWITZ and H. R. SCHUMACHER JR. (1971)
Ann Intern Med 74, 911-921
   Abstract »    PDF »
Chronic Polymyositis and Myxovirus-like Inclusions: Electron Microscopic and Viral Studies.
T. Sato, D. L. Walker, H. A. Peters, H. H. Reese, and S.-M. Chou (1971)
Arch Neurol 24, 409-418
   Abstract »    PDF »
Dermatomyositis: Electron Microscopic, Immunologic, and Tissue Culture Studies of Paramyxovirus-Like Inclusions.
K. Hashimoto, L. Robison, E. Velayos, and K. Niizuma (1971)
Arch Dermatol 103, 120-135
   Abstract »    PDF »
Ultrastructural Changes in Skeletal Muscle Induced by Colchicine.
O. N. Markand and A. N. D'Agostino (1971)
Arch Neurol 24, 72-82
   Abstract »    PDF »
Discoid Lupus Erythematosus: Electron Microscopic Studies of Paramyxovirus-like Structures.
K. Hashimoto and D. F. Thompson (1970)
Arch Dermatol 101, 565-577
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)