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Science 8 December 1967:
Vol. 158. no. 3806, pp. 1323 - 1324
DOI: 10.1126/science.158.3806.1323
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Articles

Bronchiolar and Large Alveolar Cell in Pulmonary Phospholipid Metabolism

Albert H. Niden 1

1 Department of Medicine, University of Chicago, Chicago, Illinois 60637

The nonciliated bronchiolar cells (Clara cells) lining the terminal airways actively secrete a phospholipid. In contrast, the large alveolar epithelial cells (type II, granular pneumonocyte) are active phagocytic cells. It is proposed that the Clara cell is the main source of pulmonary phospholipid production (presumably surfactant) while the large alveolar cell is responsible for its subsequent breakdown.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Clara Cells and Clara Cell 10 kD Protein (CC10).
G. Singh and S. L. Katyal (1997)
Am. J. Respir. Cell Mol. Biol. 17, 141-143
   Full Text »
Thyroid Hormone Influence upon Lung Surfactant Metabolism.
R. A. Redding, W. H. J. Douglas, and M. Stein (1972)
Science 175, 994-996
   Abstract »    PDF »
Beagle Dog Pulmonary Surfactant Lipids: Lipid Composition of Pulmonary Tissue, Exfoliated Lining Cells, and Surfactant.
R. C. Pfleger and H. G. Thomas (1971)
Arch Intern Med 127, 863-872
   Abstract »    PDF »
Alveolar Microenvironment.
K. H. Kilburn (1970)
Arch Intern Med 126, 435-449
   Abstract »    PDF »
Properties of Alveolar Cells and Tissues That Strengthen Alveolar Defenses.
S. P. Sorokin (1970)
Arch Intern Med 126, 450-463
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)