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Science 1 December 1967:
Vol. 158. no. 3805, pp. 1198 - 1200
DOI: 10.1126/science.158.3805.1198
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Articles

Experimental Allergic Encephalomyelitis in Agammaglobulinemic Chickens

Michael E. Blaw 1, M. D. Cooper 1, and R. A. Good 1

1 Department of Pediatrics and Division of Neurology, University of Minnesota Medical School, Minneapolis 55455

White Leghorn chickens were subjected to bursectomy and total body irradiation at hatching, thus rendering them agammaglobulinemic. At 4 weeks of age, these chickens and control chickens received lyophilized bovine spinal cord emulsified with complete Freund's adjuvant. Agammaglobulinemic chickens developed the lesions of allergic encephalomyelitis with the same frequency and intensity as the controls. Our findings support the contention that antibodies are not necessary for the development of experimental allergic encephalomyelitis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Spinal fluid differences in experimental allergic encephalomyelitis and multiple sclerosis.
H. Gutstein and Cohen SR (1978)
Science 199, 301-303
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Inhibition of Experimental Allergic Encephalomyelitis in Rats Severely Depleted of T Cells.
N. K. Gonatas and J. C. Howard (1974)
Science 186, 839-841
   Abstract »    PDF »
Autoimmunity in Chronic Brain Syndrome: A Preliminary Report.
J. R. Tkach and Y. Hokama (1970)
Arch Gen Psychiatry 23, 61-64
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Science. ISSN 0036-8075 (print), 1095-9203 (online)