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Science 1 December 1967:
Vol. 158. no. 3805, pp. 1193 - 1195
DOI: 10.1126/science.158.3805.1193
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Articles

Lymphocytic Choriomeningitis: Production of Antibody by "Tolerant" Infected Mice

Michael B. A. Oldstone 1 and Frank J. Dixon 1

1 Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Newborn mice infected with lymphocytic choriomeningitis virus are not immunologically tolerant to the agent but, rather, appear to make antibody to the virus. This antibody was detectable only in the kidneys, where presumably it had been deposited in the glomeruli in the form of complexes of antibody, virus, and complement.


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