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Science 1 December 1967:
Vol. 158. no. 3805, pp. 1141 - 1147
DOI: 10.1126/science.158.3805.1141
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Articles

The Chemical Production of Mutations

The effect of chemical mutagens on cells and their genetic material is discussed

C. Auerbach 1

1 Department of Genetics, University of Edinburgh

Since the discovery of the first potent mutagens over 20 years ago, progress in mutation research has been rapid. Many new mutagens, belonging to a variety of chemical classes, have been discovered, and for some of them the reaction with DNA in vitro has been established. It seems that the findings of these chemical investigations usually also apply to viruses which are treated outside the cell. This has made chemical mutagens into an important tool for the analysis of the genetic code. When DNA is treated inside the cell, its reactions would not be expected to be always identical with those observed in vitro; in one case they have, indeed, been found to be different.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
LSD and Genetic Damage.
N. I. Dishotsky, W. D. Loughman, R. E. Mogar, and W. R. Lipscomb (1971)
Science 172, 431-440
   Abstract »    PDF »
Latent Meiotic Anomalies Related to an Ancestral Exposure to a Mutagenic Agent.
K. S. Lavappa and G. Yerganian (1971)
Science 172, 171-174
   Abstract »    PDF »


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