Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 November 1967:
Vol. 158. no. 3804, pp. 1060 - 1061
DOI: 10.1126/science.158.3804.1060
Prev | Table of Contents | Next

Articles

Antihemophilic Factor Release by Perfused Liver and Spleen: Relationship to Hemophilia

John C. Norman 1, Jean-Pierre Lambilliotte 1, Yasushi Kojima 1, and Herbert S. Sise 1

1 Departments of Surgery and Medicine, Harvard Medical School and Tufts University Medical School, Boston City Hospital, Boston, Massachusetts

As judged by perfusion of isolated organs an antihemophilic factor is produced in the liver and the spleen. Perfusates (from hemophiliacs) that are deficient in the human anti-hemophilic factor stimulate production of the factor during perfusion. Apparently there is an antihemophilic-factor-stimulating substance in the plasma of hemophiliacs. The data suggest that splenic homotransplantation might alleviate the symptoms of hemophilia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Allotransplantation of Whole Spleen in Patients With Hepatic Malignant Tumors or Hemophilia A: Operative Technique and Preliminary Results.
D. L. Liu, S. Xia, J. Tang, X. Qin, and H. Liu (1995)
Arch Surg 130, 33-39
   Abstract »    PDF »
Invited Commentary.
J. C. Norman (1995)
Arch Surg 130, 39
   Abstract »    PDF »
The Role of the Splenic Macrophage in Antihemophilic Factor (Factor VIII) Synthesis.
R. B. Ponn, E. A. Kellogg, J. M. Korff, C. A. S. Pegg, H. S. Sise, and J. C. Norman (1971)
Arch Surg 103, 398-401
   Abstract »    PDF »
Clinical Review : Hematopoietic and Immunologic Tissue Grafting: Current Concepts and Indications in Pediatric Patients.
J. Githens (1971)
Clinical Pediatrics 10, 138-147
   Abstract »    PDF »
Cause of Abnormal Bleeding After Transplantation of Pig Liver Stored by a Perfusion Technique.
H. A. Perkins, R. E. May, and F. O. Beizer (1970)
Arch Surg 101, 62-68
   Abstract »    PDF »
Transplantation of the Spleen.
J. C. NORMAN, V. H. COVELLI, and H. S. SISE (1968)
Ann Intern Med 68, 700-704
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)