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Science 24 November 1967:
Vol. 158. no. 3804, pp. 1058 - 1059
DOI: 10.1126/science.158.3804.1058
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Articles

Chromosome Abnormality in Rat Leukemia Induced by 7,12-Dimethylbenz[a]anthracene

Taketoshi Sugiyama 1, Yoshinori Kurita 1, and Yasuaki Nishizuka 1

1 Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan

A high percentage of consistent chromosome abnormality, trisomy of the longest telocentric chromosome, was found in leukemias induced in rats of the Long-Evans strain by pulse doses of 7,12-dimethylbenz[a]anthracene. Cells with this abnormality were large, immature, and mononuclear and tended toward erythroblastic maturation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tumor Etiology and Chromosome Pattern.
F. Mitelman, J. Mark, G. Levan, and A. Levan (1972)
Science 176, 1340-1341
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Science. ISSN 0036-8075 (print), 1095-9203 (online)