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Science 24 November 1967:
Vol. 158. no. 3804, pp. 1049 - 1050
DOI: 10.1126/science.158.3804.1049
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Articles

"C"-Type Viral Particles in Plasma of Cats with Feline Leukemia

Thomas G. Kawakami 1, Gordon H. Theilen 1, Donald L. Dungworth 1, Robert J. Munn 1, and Sharon G. Beall 1

1 Departments of Clinical Sciences and Pathology, School of Veterinary Medicine, University of California, Davis

Linear sucrose-density gradient was used to detect and isolate typical "C"-type viral particles in plasma of cats with spontaneous and experimentally induced leukemia. The density of the agent is similar to known murine leukemia virus (1.15 to 1.17 grams per cubic centimeter). In the electron microscope the virus showed typical "C"-type particle morphology with various maturation stages. The maximum diameter of the mature viral particles in plasma was 115 millimicrons, a diameter slightly larger than budding particles observed in tissue. Leukemia was transmitted with cellular and cell-free inoculum after a 5-week period of latency.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Immunosurveillance of naturally occurring feline leukemia.
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Feline Leukemia and Sarcoma Viruses: Susceptibility of Human Cells to Infection.
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Feline Leukemia Virus: Occurrence of Viral Antigen in the Tissues of Cats with Lymphosarcoma and Other Diseases.
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Hematological Malignancies in Patients and Their Pets.
M. V. Viola (1968)
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