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Science 24 November 1967:
Vol. 158. no. 3804, pp. 1046 - 1048
DOI: 10.1126/science.158.3804.1046
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Articles

Crystal Structure of the 1 : 1 Complex of 5-Fluorouracil and 9-Ethylhypoxanthine

Sung-Hou Kim 1 and Alexander Rich 1

1 Department of Biology, Massachusetts Institute of Technology, Cambridge 02139

9-Ethylhypoxanthine and 5-fluorouracil form a 1 : 1 crystalline complex. The structure of this complex has been solved by x-ray diffraction analysis. The molecules crystallize in a monoclinic lattice and form a sheet structure in which pairs of fluorouracil molecules are held together by two hydrogen bonds. The 9-ethylhypoxanthine residues fill up the rest of the molecular sheet by forming single hydrogen bonds with each uracil pair.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)