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Science 17 November 1967:
Vol. 158. no. 3803, pp. 932 - 933
DOI: 10.1126/science.158.3803.932
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Articles

Colostral Immunoglobulin-A: Synthesis in vitro of T-Chain by Rabbit Mammary Gland

Richard Asofsky 1 and Parker A. Small Jr. 2

1 National Institutes of Health, Bethesda, Maryland 20014
2 Department of Microbiology, University of Florida, Gainesville

When minced mammary tissue from lactating rabbits was incubated in vitro with C14-labeled lysine and isoleucine, it incorporated radio-activity into colostral immunoglobulin A. The only portion of this colostral molecule with significant labeling was T-chain, with little or no labeling of light or heavy chains. It was thus demonstrated that T-chains are synthesized by mammary gland. Because the remainder of the molecule was derived from unlabeled material, in vivo it was probably derived from serum.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)