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Science 17 November 1967:
Vol. 158. no. 3803, pp. 924 - 925
DOI: 10.1126/science.158.3803.924
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Articles

Calcitonin from Ultimobranchial Glands of Dogfish and Chickens

D. H. Copp 1, D. W. Cockcroft 1, and Yankoon Kueh 1

1 Department of Physiology, University of British Columbia, Vancouver 8, Canada

Acid extracts of thyroid glands from a small shark Squalus suckleyi and domestic fowl Gallus domestica contained no detectable calcitonin activity, while very potent hypocalcemic responses were obtained in rats with similar extracts from the ultimobranchial glands of these two species. The calcitonin concentration was 4 to 40 times that present in hog thyroid, which, as in most other mammals, contains ultimobranchial tissue. The evidence suggests that calcitonin is a fundamental calcium-regulating hormone present in all higher vertebrates and that it is an ultimobranchial rather than a thyroid hormone. It also indicates an important and hitherto unrecognized function for the ultimobranchial glands.


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Calcitonin messenger RNA encodes multiple polypeptides in a single precursor.
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Polypeptide Hormones and Calcium Metabolism.
G. D. AURBACH, J. T. POTTS JR., L. R. CHASE, and G. L. MELSON (1969)
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