Slow Virus Kidney Disease of Mice
Frederick D. Baker 1 and
John Hotchin 1
1 Division of Laboratories and Research, New York State Department of Health, Albany 12201
Preliminary observations based on organ weight differential, renal function, and glomerular lesions in mice infected neonatally with lymphocytic choriomeningitis indicate the presence of a slow virus-induced kidney disease of mice. This condition is accompanied by a marked decrease in the size of the kidneys, with progressive diminution of renal function, as shown by measurements of creatinine and urea clearance.