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Science 20 October 1967:
Vol. 158. no. 3799, pp. 387 - 388
DOI: 10.1126/science.158.3799.387
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Articles

5-Oxo-5H-benzo[e]isochromeno-[4,3-b] indole, a New Type of Highly Sarcomagenic Lactone

A. Lacassagne 1, N. P. Buu-Hoi 1, F. Zajdela 1, P. Jacquigmon 1, and M. Mangane 1

1 Institut du Radium de l'Université de Paris, Paris 5e, France

The title compound, which belongs to a new synthetic group of polycyclic lactones derived from isocoumarin, exhibits a remarkably high degree of carcinogenicity in situ when injected in mice. Cancer-inducing activity has also been found in similar isocoumarins, a family known to include many naturally occurring substances.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)