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Science 20 October 1967:
Vol. 158. no. 3799, pp. 343 - 351
DOI: 10.1126/science.158.3799.343
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Articles

Chemistry and Structure of Nucleic Acids of Bacteriophages

Many forms of nucleic acids of bacteriophages show the ways that information is stored and reproduced

J. A. Cohen 1

1 Medical Biological Laboratory of the National Defense Research Organization TNO, University of Leiden, The Netherlands

The nucleic acids of bacteriophages are characterized by a surprising multiformity. RNA and DNA may occur, the latter in single- or double-stranded form, circular or linear, with or without breaks or single-strand ends. Terminal redundancy may exist and the populations of linear phages may be uniform or randomly permuted. A double-stranded circular DNA does not occur in extracellular bacteriophage, but is often if not always formed after infection of the bacterial host. Phage DNA may be glucosylated or methylated to a certain extent, and the glucose and methyl residues may influence the stability of the DNA inside the host.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)