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Science 13 October 1967:
Vol. 158. no. 3798, pp. 272 - 274
DOI: 10.1126/science.158.3798.272
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Articles

Regeneration of Rat Liver: Transfer of Humoral Agent by Cross Circulation

Frederick L. Moolten 1 and Nancy L. R. Bucher 1

1 John Collins Warren Laboratories of Huntington Memorial Hospital of Harvard University, Massachusetts General Hospital, Boston

Carotid-to-jugular cross circulation between partially hepatectomized and normal rats, via polyethylene cannulas, stimulated incorporation of 14C-thymidine into hepatic DNA in the normal partners when it was maintained for 19 hours at a flow rate of about 2 milliliters per minute. Cross circulation for 7 hours or less was ineffective.


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