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Science 22 September 1967:
Vol. 157. no. 3795, pp. 1438 - 1440
DOI: 10.1126/science.157.3795.1438
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Articles

DDT: Interaction with Nerve Membrane Conductance Changes

Toshio Narahashi 1 and Hans G. Haas 1

1 Department of Physiology, Duke University Medical Center, Durham, North Carolina 27706

The falling phase of action potentials of lobster giant axons is prolonged by DDT; finally a plateau phase is produced like cardiac action potentials. In axons poisoned with DDT, peak transient (sodium) currents associated with step depolarizations are turned off very slowly, and steady-state (potassium) currents are markedly suppressed. These two changes would cause the prolongation of action potentials and are considered the major ionic mechanisms of DDT action.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neuroreceptors and Ion Channels as the Basis for Drug Action: Past, Present, and Future.
T. Narahashi (2000)
J. Pharmacol. Exp. Ther. 294, 1-26
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Antagonism by DDT of the Effect of Valinomycin on a Synthetic Membrane.
B. D. Hilton and R. D. O'Brien (1970)
Science 168, 841-843
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Adenosine Triphosphatase Sensitive to DDT in Synapses of Rat Brain.
F. Matsumura and K. C. Patil (1969)
Science 166, 121-122
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Condylactis Toxin: Interaction with Nerve Membrane Ionic Conductances.
T. Narahashi, J. W. Moore, and B. I. Shapiro (1969)
Science 163, 680-681
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Science. ISSN 0036-8075 (print), 1095-9203 (online)