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Science 8 September 1967:
Vol. 157. no. 3793, pp. 1176 - 1177
DOI: 10.1126/science.157.3793.1176
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Articles

Orientation of Nonsense Codons on the Genetic Map of the Lac Operon

David Zipser 1

1 Department of Biological Sciences, Columbia University, New York 10027

Intracodon recombination is used to orient the nonsense codons UGA, UAG, and UAA on the genetic map of the (lactose) lac operon of Escherichia coli. The 5'-end of these triplets is toward the operator end of the operon. A hypothesis is presented to explain the fact that the frequency of recombination between adjacent nucleotides is many times lower than expected.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)