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Science 1 September 1967:
Vol. 157. no. 3792, pp. 1068 - 1070
DOI: 10.1126/science.157.3792.1068
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Articles

Viral Inhibition of Lymphocyte Response to Phytohemagglutinin

J. R. Montgomery 1, M. A. South 1, W. E. Rawls 1, J. L. Melnick 1, G. B. Olson 2, P. B. Dent 2, and R. A. Good 2

1 Departments of Pediatrics and Virology and Epidemiology, Baylor University College of Medicine, Houston, Texas 77025
2 Pediatric Research Laboratories, Variety Club Heart Hospital, and Department of Pediatrics, University of Minnesota, Minneapolis

The response to phytohemagglutinin by lymphocytes from eight of fourteen patients with congenital rubella was inhibited, whereas that of lymphocytes from patients with other diseases was not. The response of normal lymphocytes infected in vitro was also inhibited. The results suggest that early association of lymphocytes with virus inhibits the function of the cell and contributes to persistent carrying of virus in congenital rubella. This phenomenon may be a means of detecting viruses not now recognizable by routine methods of tissue culture.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunologic Dysfunction in Heroin Addicts.
S. M. Brown, B. Stimmel, R. N. Taub, S. Kochwa, and R. E. Rosenfield (1974)
Arch Intern Med 134, 1001-1006
   Abstract »    PDF »
Immunologic Deficiency in the Congenital Rubella Syndrome.
R. N. Schimke, C. Bolano, and C. H. Kirkpatrick (1969)
Arch Pediatr Adolesc Med 118, 626-633
   Abstract »    PDF »
Effects of Rubella Virus Infection on the Division of Human Cells.
A. Boue and J. G. Boue (1969)
Arch Pediatr Adolesc Med 118, 45-48
   Abstract »    PDF »
Congenital Rubella Syndrome: Lymphoid Tissue and Immunologic Status.
D. B. Singer, M. A. South, J. R. Montgomery, and W. E. Rawls (1969)
Arch Pediatr Adolesc Med 118, 54-61
   Abstract »    PDF »
Mycoplasma Inhibition of Phytohemagglutinin Stimulation of Lymphocytes.
L. Spitler, K. Cochrum, and H. H. Fudenberg (1968)
Science 161, 1148-1149
   Abstract »    PDF »
Effect of Amantadine Hydrochloride on the Response of Human Lymphocytes to Phytohemagglutinin.
W. E. Rawls, J. L. Melnick, G. B. Olson, P. B. Dent, and R. A. Good (1967)
Science 158, 506-507
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)