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Science 1 September 1967:
Vol. 157. no. 3792, pp. 1064 - 1065
DOI: 10.1126/science.157.3792.1064
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Articles

Herpes-Type Virus and Chromosome Marker in Normal Leukocytes after Growth with Irradiated Burkitt Cells

Werner Henle 1, Volker Diehl 1, Gertrude Kohn 1, Harald zur Hausen 1, and Gertrude Henle 1

1 Children's Hospital of Philadelphia and School of Medicine, University of Pennsylvania, Philadelphia 19146

Cultured cells derived from male patients with Burkitt's lymphoma and harboring herpes-type virus particles were lethally irradiated. These irradiated cells induced normal peripheral leukocytes of female infants to grow within 2 to 4 weeks after mixed cultivation. Cells of a line free of this agent failed to stimulate growth. If either type of cell was cultured separately, it did not survive under the experimental conditions. Herpes-type viral antigen and C-group chromosomal marker previously described in cultured Burkitt cells were found in all of the female cell cultures that were obtained.


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