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Science 25 August 1967:
Vol. 157. no. 3791, pp. 950 - 951
DOI: 10.1126/science.157.3791.950
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Articles

Chemoprophylactic Agent in Schistosomiasis: 14,15-Epoxygeranylgeraniol

Walter B. Mors 1, Miguel Fascio dos Santos Fo. 1, Hugo J. Monteiro 1, B. Gilbert 1, and J. Pellegrino 2

1 Centro de Pesquisas de Produtos Naturais, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
2 Instituto de Biologia, Faculdade de Filosofia, Universidade Federal de Minas Gerais, and Centro de Pesquisas René Rachou, Ministério de Saúde, Belo Horizonte, Brazil

The occurrence of all-trans (-)-14,15-epoxygeranyl-geraniol in Pterodon pubescens Benth. is established, and its prophylactic activity against infection by Schitsosma mansoni demonstrated. Two other diterpenes present in the oil are inactive.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)