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Science 25 August 1967:
Vol. 157. no. 3791, pp. 930 - 931
DOI: 10.1126/science.157.3791.930
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Articles

Immunoglobulin A: Localization in Rectal Mucosal Epithelial Cells

Eugene A. Gelzayd 1, Sumner C. Kraft 1, and Frank W. Fitch 1

1 Departments of Medicine and Pathology, University of Chicago School of Medicine, Chicago 60637

Immunofluorescence studies with monospecific antiserums to human serum immunoglobulins consistently revealed immunoglobulin A within the apical portion of the cytoplasm of rectal mucosal epithelial cells in normal subjects, as well as in patients with various bowel diseases. Immunoglobulins M, G, and D were not demonstrated within mucosal epithelial cells. The predominance of lymphoid cells containing immunoglobulin A in the lamina propria of intestinal tissues was confirmed.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)